Ozone therapy for Peyronie’s disease is not an established approach for this condition in Portugal. Nevertheless, some men seek this technique hoping to reduce inflammation, fibrosis or penile curvature.

Treatment for Peyronie’s disease with ozone therapy requires caution. To date, there is no robust clinical evidence that ozone can reduce symptoms or act on the underlying cause of the condition.

Ozone therapy uses a mixture of oxygen and ozone for therapeutic purposes. Although its potential anti-inflammatory and antioxidant effects have been studied in different areas of medicine, its specific use in Peyronie’s disease remains without sufficient scientific validation.

For this reason, any non-conventional therapy should be reviewed with a specialist urologist before it is considered. Established approaches selected according to the characteristics of each case should be prioritized.

What Is Ozone Therapy?

Ozone therapy consists of the medical use of a mixture of oxygen and ozone. The route of administration, concentration and frequency vary among protocols.

This use began to develop in the early twentieth century because of its antimicrobial properties. It has been studied in different fields for potential effects on the inflammatory response, oxidative stress and healing processes.

In Peyronie’s disease, it is hypothesized that ozone therapy may modulate the inflammatory response and oxidative stress during the active phase of the disease. In theory, these effects could contribute to pain control or interfere with the inflammatory process associated with plaque formation.

However, a biologically plausible mechanism does not establish clinical effectiveness. Findings observed in other diseases or tissues cannot be automatically applied to Peyronie’s disease. Specific, controlled, high-quality studies are needed to determine whether an intervention is effective and safe for the penis.

Does Ozone Therapy for Peyronie’s Disease Produce Effective Results?

At present, there is insufficient scientific evidence to establish the effectiveness of penile ozone therapy for Peyronie’s disease. This technique is not included in the European Association of Urology recommendations for treating this condition.

There are also no robust data showing that ozone can potentially eliminate the plaque, stop disease progression or straighten the penis.

For these reasons, ozone therapy should not replace approaches evaluated in clinical studies or delay diagnosis.

If presented as an adjunctive or experimental option, the patient should be clearly informed about the lack of proven benefits and the uncertainties regarding safety.

Recommended and Validated Treatment Approaches

The management of Peyronie’s disease should be defined according to the stage of the disease, pain intensity, degree and type of curvature, erectile function and the impact of the deformity on sexual activity.

According to European Association of Urology guidelines, conservative options are used mainly in the active phase, while surgery is generally reserved for stable disease with functional impairment.

Potentially validated alternatives that may be indicated by the urologist after an individualized assessment include:

• Medications for pain control;
• Medications for erectile dysfunction;
• Intralesional injections;
• Adjunctive therapies (shockwave therapy, penile traction and vacuum devices);
• Penile surgery. 

Frequently Asked Questions

Can Ozone Therapy Cure Peyronie’s Disease?

There is no clinical evidence that ozone therapy alone treats Peyronie’s disease.

What Are the Risks of Applying Ozone to the Penis?

Inappropriate application may cause pain, bruising, infection or injury to the corpora cavernosa. Any procedure should be performed exclusively by qualified healthcare professionals.

When Should You See a Urologist for Peyronie’s Disease?

It is important to see a urologist in the event of pain during erection, the appearance of a lump, acquired curvature, narrowing or loss of penile length, erectile dysfunction or difficulty during sexual intercourse.

The patient is encouraged to follow medical guidance and carefully consider alternative therapies for Peyronie’s disease, which may potentially delay appropriate treatment or cause complications.

Seek a Specialist Assessment

Before choosing ozone therapy for Peyronie’s disease or any other therapy, it is important to have an assessment with a urologist.

For a safe review of the clinical case, it is recommended to contact a qualified healthcare professional to schedule a consultation.